Boehringer Ingelheim
Scientist - Oligonucleotide Synthesis Expert, Medicinal Chemistry (m/w/x)
Vollzeitnur vor OrtJunior
Biberach
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BOBoehringer Ingelheim
Principal Scientist | Oligonucleotide Discovery Platform & RNA Therapeutics (m/w/x)
VollzeitVor OrtBerufserfahren
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Leading oligonucleotide synthesis and characterization for RNA therapeutics. PhD in chemistry or related field, with hands-on expertise in oligonucleotide synthesis and characterization required. Wellbeing package, comprehensive benefits.
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Anforderungen
- PhD in organic chemistry, medicinal chemistry, nucleic acid chemistry, biochemistry, or related discipline
- Industrial or academic experience in oligonucleotide therapeutics and RNA-targeting drug discovery
- Strong hands-on expertise in oligonucleotide synthesis, purification, and analytical characterization
- Deep understanding of siRNA design principles, chemical modification strategies, and conjugate technologies
- Experience with GalNAc-siRNA, extrahepatic delivery technologies, or oligonucleotide-targeting ligands is highly desirable
- Entrepreneurial mindset with enthusiasm for building new scientific capabilities and platforms
- Experience leading research projects in an industry setting is an advantage
- Prior experience establishing an oligonucleotide laboratory or serving as manager is an advantage; thorough familiarity with relevant instrumentation expected
- Team-oriented and collegial attitude with profound communication skills
- Proficient oral and written communication skills in English and willingness to adopt basic German
Aufgaben
- Establish, operate, lead, and advance the oligonucleotide synthesis and characterization laboratory
- Serve as scientific lead for oligonucleotide chemistry, RNA modification, and conjugate technologies
- Design, synthesize, purify, and characterize siRNAs, modified oligonucleotides, and conjugates
- Develop chemical solutions for improved potency, durability, safety, and delivery of RNA therapeutics
- Drive identification, evaluation, and implementation of novel RNA-targeting technologies and delivery concepts
- Build expertise in extrahepatic delivery strategies and tissue-targeted RNA therapeutics
- Collaborate with biology, DMPK, translational medicine, pharmaceutical sciences, and external partners
- Contribute to target assessment and modality selection for RNA-based approaches
- Lead oligonucleotide-based projects and drive drug discovery programs from ideation to development candidate
- Identify opportunities for proprietary innovation and develop intellectual property positions
- Support development of differentiated platform technologies and contribute to patent filings
- Establish external scientific networks and monitor technological developments
- Present research findings and project updates to internal and external stakeholders
- Mentor scientists and contribute to the development of oligonucleotide strategy
Berufserfahrung
ca. 1 - 4 Jahre
Ausbildung
Doktor / Ph.D.
Sprachen
Deutsch – Grundkenntnisse
Englisch – verhandlungssicher
Tools & Technologien
oligonucleotide synthesissiRNA designGalNAc-siRNA
Benefits
Sonstige Vorteile
- Comprehensive benefits package
Mentale Gesundheitsförderung
- Wellbeing package
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